Advance Brain Health with Genomics & AI
THE LABORATORY OF NEUROGENOMICS
From single-cell and spatial omics to machine learning and functional genomics, we advance genomic tools to understand the genetic basis of human brain health and disease.
THE CHALLENGE
Understanding the human brain remains the humanity’s final frontiers. Its extraordinary complexity—more than billions of cells and thousands of molecularly distinct cell types—has historically limited our ability to chart its fundamental operating principles. We focus to understand how these distinct cell types are functionally connected to sustain homeostatic cellular states in the healthy brain, how these interactions become disrupted in disease, and whether targeted reprogramming of cellular networks can restore function and extend brain health and longevity.
THE APPROACH
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MAP
We develop next-generation spatial omics to map the healthy and diseased human brain at molecular resolution with unprecedented population scale.
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MODEL
We aim to apply AI and machine learning to large-scale spatial omics data to model the tissue microenvironment of the diseased brain and accelerate the development of personalized therapeutics.
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UNDERSTAND
We use high-throughput genomics and biochemical approaches to identify mechanisms by which specific genes and signaling pathways causally drive aberrant cellular phenotypes in the diseased brain.
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CURE
Ultimately, we hope to transform discovery into therapy via targeted reprogramming of pathological cellular interactions using genetic and pharmacological approaches to restore healthy brain function.